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Lung cancer, the top reason for TGF beta 2/TGFB2, Human cancer-related death in most countries, has been escalating quickly in China for the final 3 decades [1]. The risk of lung cancer is strongly connected with exposure to environmental carcinogens, in particular to cigarette smoke [2]. However, only about 10 of smokers ever create lung cancer. This highlights the prospective role of hereditary elements in determining the danger of lung cancer [3]. By means of genome-wide association studies (GWAS), a number of genes involved in lung carcinogenesis have already been identified in populations of European descent. Thesewww.impactjournals/oncotargetinclude CHRNA5, CHRNA3 and CHRNA4 on chromosome 15q25.1 [4sirtuininhibitor], (TERT-CLPTM1L) on 5p15.33 [7, 8], and (BAT3-MSH5) on 6p21.33 [7]. It was also learned from GWAS that inherited single nucleotide polymorphisms (SNPs) in telomere-related genes are associated with vario.