Product Name :
Gyrophoric acid
Description:
Gyrophoric acid is a good ultraviolet filter in lichen populations. Gyrophoric acid shows DPPH radical scavenging activity with an IC50 value of 105.75 µg/ml.
CAS:
548-89-0
Molecular Weight:
468.41
Formula:
C24H20O10
Chemical Name:
4-[4-(2,4-dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoyloxy]-2-hydroxy-6-methylbenzoic acid
Smiles :
CC1C=C(C=C(O)C=1C(O)=O)OC(=O)C1=C(O)C=C(C=C1C)OC(=O)C1=C(O)C=C(O)C=C1C
InChiKey:
ATQPZSQVWCPVGV-UHFFFAOYSA-N
InChi :
InChI=1S/C24H20O10/c1-10-4-13(25)7-16(26)20(10)23(31)34-15-6-12(3)21(18(28)9-15)24(32)33-14-5-11(2)19(22(29)30)17(27)8-14/h4-9,25-28H,1-3H3,(H,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Gyrophoric acid is a good ultraviolet filter in lichen populations. Gyrophoric acid shows DPPH radical scavenging activity with an IC50 value of 105.75 µg/ml.|Product information|CAS Number: 548-89-0|Molecular Weight: 468.41|Formula: C24H20O10|Chemical Name: 4-[4-(2,4-dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoyloxy]-2-hydroxy-6-methylbenzoic acid|Smiles: CC1C=C(C=C(O)C=1C(O)=O)OC(=O)C1=C(O)C=C(C=C1C)OC(=O)C1=C(O)C=C(O)C=C1C|InChiKey: ATQPZSQVWCPVGV-UHFFFAOYSA-N|InChi: InChI=1S/C24H20O10/c1-10-4-13(25)7-16(26)20(10)23(31)34-15-6-12(3)21(18(28)9-15)24(32)33-14-5-11(2)19(22(29)30)17(27)8-14/h4-9,25-28H,1-3H3,(H,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Miconazole} site|{Miconazole} Antibiotic|{Miconazole} Technical Information|{Miconazole} Formula|{Miconazole} custom synthesis|{Miconazole} Epigenetics} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Gyrophoric acid (200 μM) leads to significant decrease of mitochondrial membrane potential in ovarian cancer cells A2780 after 24 h long exposure but not in HT-29 colon adenocarcinoma cells.{{24(S)-Hydroxycholesterol} web|{24(S)-Hydroxycholesterol} Metabolic Enzyme/Protease|{24(S)-Hydroxycholesterol} Purity & Documentation|{24(S)-Hydroxycholesterol} In Vivo|{24(S)-Hydroxycholesterol} custom synthesis|{24(S)-Hydroxycholesterol} Epigenetics} Gyrophoric acid significantly inhibits cell growth and affects the expression of Bcl-2, Bax and Hsp70 proteins but only on higher concentration in A375 melanoma cancer cells.PMID:24516446 Gyrophoric acid treatment on HeLa cells clearly indicates ROS production and apoptosis as form of occurred cell death. Moreover, DNA damage and changing activity of stress/survival proteins as p38MAPK, Erk1/2 and Akt mediated by Gyrophoric acid treatment confirm pro-apoptotic potential.|Products are for research use only. Not for human use.|
