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Zhang et al. Parasites Vectors (2015)eight:37 DOI 10.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1AbstractBackground: Schistosomiasis is really a chronic parasitic disease that affects roughly 200 D2 Receptor Inhibitor custom synthesis million persons. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation of your granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected folks could result in chronic liver fibrosis and circulatory impairment. Therefore, elucidation with the mechanisms of these responses won’t only give additional info to far better comprehend the mechanisms of your immunoregulation in schistosomiasis, but additionally assistance to design and style new therapies to manage granuloma-associated immunopathology. The role of aquaporin-4 (AQP4) in water transport has been extensively investigated within the central nervous system (CNS). Recently, research have shown that AQP4 expresses in immune system and lack of AQP4 in mice outcomes in considerably significantly less CD4+CD25+ T regulatory cells (Treg cells) below physiological condition, certainly one of the subpopulations of CD4+T cells which restrains immunopathology in hosts with schistoso.