Product Name :
Rabbit anti-UBE3C Polyclonal Antibody(Center)
Synonym :
Ubiquitin-protein ligase E3C; 632-; HectH2; UBE3C; KIAA0010; KIAA10
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This UBE3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the Central region of human UBE3C.
Predicted Reactivity:
Applications :
WB~~1:1000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cell Biology
Background :
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either ‘Lys-29’- or ‘Lys-48’-linked polyubiquitin chains. Has preference for ‘Lys-48’ linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
UniProt :
Q15386
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Ubiquitin-protein ligase E3C; 632-; HectH2; UBE3C; KIAA0010; KIAA10 |Host Rabbit |Specificity This UBE3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the Central region of human UBE3C. |Species Reactivity Human |Applications WB~~1:1000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cell Biology |Target |Background E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either ‘Lys-29’- or ‘Lys-48’-linked polyubiquitin chains. Has preference for ‘Lys-48’ linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. |Cellular localization Nucleus. |UniProt Q15386 |References |References Nomura N., et al. DNA Res. 1:27-35(1994).Hillier L.W., et al. Nature 424:157-164(2003).Scherer S.W., et al. Science 300:767-772(2003).Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.You J., et al. J. Biol. Chem. 276:19871-19878(2001). |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-UBE3C Polyclonal Antibody(Center)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
2296729-00-3 manufacturer 2766385-56-0 manufacturer PMID:29763127 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
